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In a study of 80 obese people with type 2 diabetes receiving semaglutide and dulaglutide, a 20% reduction in the thickness of EAT was observed (62) One meta-analysis demonstrated the cardioprotective effects of GLP-1 RAs, showing reductions in blood pressure and lipid profile, with a significant increase in HDL levels (63)

In that case, you should give your doctor a call

The preclinical evidence compiled in animal models, however, offers a highly dependable, reproducible dataset demonstrating accelerated soft tissue remodeling, localized capillary formation, and cellular matrix organization

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Your endocrinologist will verify normalization of 24-hour urinary free cortisol, morning serum cortisol, and late-night salivary cortisol before approving weight loss interventions